Effect of high dose of pyridoxine on mammary tumorigenesis.

نویسندگان

  • Dai Shimada
  • Ayumi Fukuda
  • Hiroaki Kawaguchi
  • Norihisa Kato
  • Hiroki Yoshida
  • Hiroaki Kanouchi
  • Tatsuzo Oka
چکیده

The effect of high-dose pyridoxine (PN) on mammary tumorigenesis was examined in female Sprague-Dawley rats. The first mammary tumors appeared between 84 and 90 days after 7,12-dimethylbenzanthracene treatment. There was no effect of PN level on tumor incidence at 90 days but at 98, 104, and 111 days. Tumor incidence was lower in the high-dose group (35 mg PN/kg diet) compared with the controls (7 mg PN/kg diet). All tumors were identified as adenocarcinoma and most as papillary type. The number of microcarcinomas in mammary glands of the 35-mg PN group tended to be reduce than that of the 7-mg group. The number of proliferating Ki67-positive cells was significantly reduced by supplementation with PN.

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عنوان ژورنال:
  • Nutrition and cancer

دوره 53 2  شماره 

صفحات  -

تاریخ انتشار 2005